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KMID : 0360319950270030468
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Journal of Korean Cancer Research Association
1995 Volume.27 No. 3 p.468 ~ p.474
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A Study of Three-group Metaphase as a Prognostic Factor in Cervical Cancer
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Abstract
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The biologic behavior of cervical neoplasia has been reported to be predicted by determining the ploidy pattern. The determination of the ploidy status by DNA cytometry on cells from tissue samples is yet too cumbersome for routine use.
Three-group
methaphase was defined as a mitotic figure in which a number of chromosomes remain at both poles of spindle and the majority of chromosomes from the metaphase plate. This atypical mitotic figures caused by an abnormal distribution of chromosomes
resulting from detects in the movements of chromosomes. We investigate the possibility that three-group metaphase can be regarded as a histologic criterion to predict prognosis in cervical tumor. We evaluated 22 specimen with cervical
intraepithelial
neoplasia, 4 specimen with carcinoma in situ, 11 specimen with invasive cervical cancer and 3 specimen with chronic cervicitis in cone biopsy or punch biopsy to investigate the frequency of three-group metaphase using formalin-fixed paraffin
embedded
tissue from january 1992 to December 1993. Three-group metaphase was found 1 case of the invasive cervical cancer and 1 case of the microinvasive cervical cancer combined with cervical intraepithelial neoplasia lesion from cone biopsy. However
three-group metaphase was not found in cervical intraepithelial neoplasia and carcinoma insitu lesion from cone or punch biopsy. In this study, three-group metaphase could be practically used as pathologic criterion to predict prognosis in
cervical
tumor.
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